Martin Tolar Selected Research

tramiprosate

1/2020	APOE ε4/ε4 homozygotes with early Alzheimer's disease show accelerated hippocampal atrophy and cortical thinning that correlates with cognitive decline.
1/2018	Clinical Pharmacokinetics and Safety of ALZ-801, a Novel Prodrug of Tramiprosate in Development for the Treatment of Alzheimer's Disease.
1/2018	Discovery and Identification of an Endogenous Metabolite of Tramiprosate and Its Prodrug ALZ-801 that Inhibits Beta Amyloid Oligomer Formation in the Human Brain.
6/2017	Elucidating the Aβ42 Anti-Aggregation Mechanism of Action of Tramiprosate in Alzheimer's Disease: Integrating Molecular Analytical Methods, Pharmacokinetic and Clinical Data.

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Martin Tolar Research Topics

Disease

7	Alzheimer Disease (Alzheimer's Disease) 06/2021 - 06/2017
2	Disease Progression 06/2021 - 12/2020
2	Amyloid Plaque 06/2021 - 12/2020
2	Cognitive Dysfunction 01/2020 - 01/2011
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2018 - 06/2017
1	Edema (Dropsy) 12/2020
1	Cerebral Cortical Thinning 01/2020
1	Atrophy 01/2020
1	Vomiting 01/2018
1	Memory Disorders (Memory Loss) 01/2018
1	Nausea 01/2018

Drug/Important Bio-Agent (IBA)

4	Amyloid beta-PeptidesIBA 06/2021 - 06/2017
4	Amyloid (Amyloid Fibrils)IBA 06/2021 - 01/2018
4	tramiprosateIBA 01/2020 - 06/2017
3	ALZ-801IBA 12/2020 - 01/2018
2	ApolipoproteinsIBA 06/2021 - 01/2020
2	Apolipoprotein E4IBA 06/2021 - 12/2020
2	Biomarkers (Surrogate Marker)IBA 12/2020 - 01/2020
2	Apolipoproteins E (ApoE)IBA 01/2020 - 01/2011
2	Pharmaceutical PreparationsIBA 01/2018 - 06/2017
1	aducanumabIBA 12/2020
1	lecanemabIBA 12/2020
1	gantenerumabIBA 12/2020
1	ProdrugsIBA 01/2018
1	Proteins (Proteins, Gene)FDA Link 06/2017

Therapy/Procedure

2	Therapeutics 11/2020 - 06/2017